Our two genius roommates, Leonard and Sheldon, and their friends are back once again (smarter, but no wiser). Last season, Sheldon went soul-searching (on a train, of course) and was prepared to make some substantial revisions on his Relationship Agreement with Amy, when everything changed. Leonard, meanwhile, was off to Vegas with Penny to finally tie the knot in the season finale. Howard finds himself alone with Bernadette after the sudden passing of his mother; while Raj is not only talking to women – he’s getting exclusive with Emily. Together, they will all learn that life is far more complicated outside of the lab as love and friendship never produce predictable results!
After driving to Vegas to get married, Penny struggles with Leonard’s confession that he kissed another girl. Also, Sheldon doesn't know how to act after Amy pushes pause on their relationship.
Leonard confronts the woman he kissed on the North Sea in an attempt to set Penny's mind at ease. Also, Sheldon films a special episode of "Fun with Flags" after his breakup with Amy, and Bernadette feels guilty about withholding a secret from Penny.
The guys' science skills are put to the test when they get a flat tire during Leonard's bachelor party weekend in Mexico. Also, the girls force Penny to finally tell her family that she eloped with Leonard.
Sheldon learns of an impending change in his living arrangements and decides to revert back to 2003, a simpler time before he met Leonard and Penny. Also, Howard and Raj form a band to play at the Comic Book Store.
The guys take a fencing lesson from Barry Kripke and Sheldon finds himself in an awkward position when Kripke expresses interest in Amy. Also, when Stuart struggles to get female customers at the Comic Book Store, Penny, Amy and Bernadette come by to help him out.
In the midst of a nation-wide helium shortage, Sheldon and Leonard take desperate measures to get the supplies they need. Also, Penny and Bernadette download a dating app on Amy's phone to try and find her a new man.
Wil Wheaton interviews Sheldon for a Star Trek documentary where he reveals the ring and his plan to propose to Amy. Bernadette wants to start renovating the house and the topic of starting a family together with Howard is brought up.
Sheldon, Wolowitz and Koothrappali post an online advertisement to find Sheldon a new girlfriend. Also, when Amy is coy with details about a guy she is dating, Penny and Bernadette decide to spy on her.
Sheldon and Amy try hanging out as friends when they spend Thanksgiving together at the aquarium. Also, Wolowitz reluctantly agrees to volunteer at the soup kitchen with Bernadette, Raj and Emily, and Penny discovers that Leonard knows more about her than she thought.
Sheldon has a revelation when he realizes why a song was stuck in his head. Also, Amy invites Dave over for dinner despite their previously awkward date, and Wolowitz and Koothrappali become obsessed with a fan of their band, "Footprints on the Moon".
After more than five years of dating, Sheldon and Amy spend their first night together. Also, Leonard, Wolowitz, and Koothrappali must decide who will take their extra Star Wars movie ticket.
Penny gets more than she bargained for when Leonard agrees to meet with a psychiatrist on her behalf. Also, Sheldon and Koothrappali collaborate on an astronomical discovery, and Wolowitz and Bernadette can't believe what they are feeling after Stuart moves out.
Meemaw meets Amy, but it isn't all roses. Meemaw seems to have an axe to grind with her. Sheldon comes to Amy's defense, but not before Meemaw lets a little secret of his slip.
Sheldon and Amy host a live Valentine's Day episode of Fun with Flags, Leonard and Penny grapple with getting older, Howard and Bernadette find a surprise in their hot tub and Raj is torn between Emily and the cute girl he met at the Comic Bookstore.
When the gang finds out about Bernadette’s pregnancy, they celebrate by singing karaoke. Also, Bernadette is concerned when Wolowitz freaks out over her pregnancy announcement, and Wolowitz is convinced he must make more money to provide for the baby.
Leonard, Sheldon, and Wolowitz run into problems when they file for a patent for their infinite persistence gyroscope. Also, Penny, Amy and Bernadette give Koothrappali dating advice when Emily reaches out to him after their breakup.
Amy is shocked at a revelation from Sheldon after she buys him a new laptop. Also, Koothrappali sells out Leonard and Wolowitz after they lie to their wives in order to attend an early screening of a movie.
Sheldon spills a secret of Leonard’s when the two take a weekend cabin trip with Penny and Amy. Also, when Koothrappali goes overboard with pregnancy gifts, Wolowitz and Bernadette must draw the line.
The gang goes to a wine bar and runs into Penny’s old boyfriend, Zack. Also, Bernadette gets stuck spending the evening with Sheldon when she can’t go wine tasting with the group, and things don’t go as planned when Koothrappali introduces his new girlfriend, Claire.
Sheldon hires Stuart to spend the day with Amy when he’d rather go to a movie screening. Also, Leonard’s mother, Beverly, comes to town and Penny struggles to make a connection with her.
Chaos ensues when Leonard’s recently divorced parents, Alfred and Beverly, and Sheldon’s devoutly religious mother, Mary, come to town. Also, Wolowitz and Koothrappali think the government is out to get them when they are contacted about their guidance system.