Meddling Mama Beverly and Murray are faced with an (almost) empty nest! Last year, eldest kid Erica decided the life of wanna-be rockstar wasn’t for her, so she set her sights on heading back to school and actually trying this time. Meanwhile, hot-tempered middle child Barry has graduated and is ready to move on from his longtime love, Lainey Lewis, and reinvent himself in college. The only catch is that both Erica and Barry are headed to the same school! That leaves the youngest and resident geek Adam as the only Goldberg child left in the house. Adam’s year will be legendary too as he navigates life as a nerdy upperclassmen, while still facing nefarious bullies, social anxieties and maybe even the return of a “first” love he thought moved away. As Beverly zeroes her smothering powers in on her last schmoopie at home, Murray decides to make a real effort for the first time in his life.
Beverly insists the family take a road trip to go on vacation to Disneyland before Erica and Barry go off to college; Erica worries about her relationship with Geoff when he tells her they need to talk.
When a job for Geoff Schwartz's new food delivery service goes awry, it's up to Murray and Geoff to race all over Jenkintown in search of an important cheesesteak; a handful of local customers are anything but helpful.
While at school, Erica attempts to fool Beverly into thinking Parents Weekend has been rescheduled to Parents Thursday so the family won’t attend. Meanwhile, William Penn is doing “Romeo & Juliet,” the perfect play for Adam to romance Dana until someone else gets the leading lady.
Beverly scores a bargain on four paintings. Once they make it home, she and Adam determine something supernatural is causing them to be destroyed. Much to Murray's dismay, they call a psychic for help. Meanwhile, Barry decides to throw a huge "Rocky Horror Picture Show"-themed party against Erica's wishes. Their confrontation leads to a visit to the dean's office.
Murray buys WrestleMania tickets to spend time with Barry and Adam, but he buys fake tickets and they can't get in; Beverly forms her own neighborhood watch group when the Frentas decide neighbor Jane Bales will be the watch captain.
Beverly's patience with Pop Pop is put to the test due to his endless Thanksgiving demands; Barry and Erica are ready to return home for the holiday, but Uncle Marvin accidentally drives them to Pittsburgh.
Beverly Goldberg (Wendi McLendon-Covey) is famous in her own home for making delicious, and thoroughly unhealthy, dishes for her family to enjoy, but when she tries to get her recipes published as a cookbook, no one seems interested.
Hoping to outdo the Kremp family, Beverly decides the Goldbergs must do an even better family holiday card; a prank war with Barry and JTP quickly spirals out of control.
Beverly discovers Murray is actually a year younger than they knew so she plans a do-over at celebrating his 50th birthday, while Coach Mellor attempts to prepare non-athletic Adam for tryouts for pickleball.
Geoff struggles to keep his living arrangement with Erica and Barry a secret from Beverly during game night, while Adam goes to his guidance teacher for a lesson in being cool so he can get closer to a new girl in chemistry class.
Adam questions his career path of filmmaking when "the other Adam" moves back from Los Angeles and warns him making it big in Hollywood isn't easy. Meanwhile, the JTP house is in shambles, and Geoff becomes the home manager as they know how much he loves to please and can't say no.
When Erica and Barry receive the same grade in class, Erica knows something's up and finds out something very interesting about her brother. Meanwhile, Beverly gets involved to help Adam win his crush as a date for the upcoming Cupid Couples' Skate at William Penn Academy.
A big party is being thrown at Dave Kim's house and Pops has a plan to make Adam cool for the big event. Meanwhile, Beverly's cookbook has made her "famous," leading her to become out of control and fame-hungry, but eventually she learns an important lesson.
Adam is torn between following Beverly's rules when it comes to off-campus lunch or going to the mall food court with his friends. Meanwhile, after using Barry's college ID to get food at the dorm, Geoff goes overboard and becomes the "student" Barry wishes he could be.
Despite Beverly's insistence, Adam and Murray don't want to go on a camping trip, so father and son create a film faking it, but their wilderness experience backfires when the Kremps come over for dinner.?Meanwhile, Erica joins an all-girl a cappella group and learns an important lesson after taking over the group.
Mother and son have a bonding experience when Beverly buys a bicycle for Adam just like the one from “Pee Wee’s Big Adventure,” while Barry and Erica turn Murray’s furniture store into an after-hours lounge for college students.
Erica, Barry, Geoff and the JTP go on a spring break trip and things are not what they expect. Meanwhile, Adam questions if college is for him when his test scores are not as good as he was hoping for.
Business rival and nemesis "Formica" Mike attempts to make an offer Murray can't refuse by buying Ottoman Empire. Meanwhile, Adam offers Ms. Cinoman his and Erica's original show when William Penn cannot secure the rights to a well-known spring musical to stage.
While throwing a telethon at their college to raise money for Earth Day, Barry attempts to woo Ren when he overpromises he can get Hall & Oates to perform. Meanwhile, Beverly attempts to set Bill up, but things go awry when he finds happiness with a woman he meets through Beverly's enemy
Adam and Brea's relationship is going well until Beverly's over-involvement causes them to fake a breakup. Meanwhile, Lainey is back in Jenkintown which throws Barry for a loop regarding his blossoming relationship with Ren.
Adam and Brea decide to go to prom together, but when Adam worries he won't be Prom King, Beverly's actions jeopardize the event. Meanwhile, Barry teaches Erica how to be compassionate and caring when Geoff's dad is in the hospital.